Ministerio de Ciencia e Innovación

Tackling frailty. Detection, screening, diagnosis and treatment


Frailty is a clinical-healthcare problem caused by and resulting from disease. One of today’s challenges is the early detection of the syndrome, in the frailty stage. This entails the need to identify the risk factors leading to frailty and to use these in a screening policy enabling preventive interventions. In a more advanced stage, the diagnosis and classification of individuals as robust, pre-frail and frail should lead to interventions preventing the negative progression of the function or which reverse the syndrome.

General objective

Identification of risk factors enabling sensitive and clinically-viable screening scales to be prepared. Identification of robust and efficient biomarkers of frailty in their different stages. Development of primary and secondary prevention action for the frailty syndrome. Construction of clinical channels modifying the adverse effect of multimorbidity, polypharmacy and socio-environmental factors. An economic evaluation of the performance of the interventions. Development of information technologies facilitating extensive and efficient implementation of the interventions.

Lines of research

  1. Analysis of healthcare records(big data) and cohort studies.
  2. Application of screening and early detection tools.
  3. Identification of clinical biomarkers of fragility, including markers of the musculoskeletal system.
  4. Interventions on individuals, clinically uniform groups or systematic measures on different healthcare levels.
  5. Assessment of results and of socio-economic impact.

Attached Groups

For further information about groups working in this research programme visit the Spanish version